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Model reference · open weights

BioMistral

LLMs BioMistral Text gen 1 build Open weights 53k dl/mo

BioMistral is an open-weight language model from BioMistral. BioMistral-7B (BF16) weighs 14.5 GB; the smallest configuration that runs it is RTX 4060 Ti 16 GB.

  • BioMistral is a 7B parameter open-source large language model designed for text generation in the biomedical domain.
  • It is based on Mistral-7B-Instruct-v0.1 and further pre-trained on PubMed Central data, supporting a sequence length of 2048 tokens.
  • The model is released under the Apache-2.0 license and supports French, English, German, Dutch, Spanish, Portuguese, Polish, Romanian, and Italian.

Summary of the BioMistral/BioMistral-7B model card, 2026-10-01

Hugging Face ↗Paper ↗

What it is

Released byBioMistral
Released2024-02-14
VRAM14.5 GB for the weights

What it runs on

Memory and cards for BioMistral-7B (BF16)

14.5 GBweights, file size
762 MBruntime overhead, at least

How much memory each request adds isn't estimated yet for this architecture. The weights need at least the cards below, plus room for the context.

CardWeights alone
RTX 3060 12 GBdoes not fit
RTX 4060 Ti 16 GBtight
RTX 3090 24 GBfits
RTX 4090 24 GBfits
RTX 5090 32 GBfits
L40S 48 GBfits
A100 80 GBfits
H100 80 GBfits
RTX PRO 6000 Blackwell 96 GBfits
DGX Spark (GB10) 128 GB unifiedfits
H200 141 GBfits
B200 180 GBfits

How it works

How language models work

Your prompttext / messagesTransformerattention over tokensNext-token loopgenerate + streamResponsetext · tool callsA language model reads your tokens and predicts the next one, again and again, streaming the reply back.
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